Granulosa cell tumour of the ovary belongs to which WHO classification category and characteristically secretes which hormone responsible for its feminizing effects?

• A Surface epithelial-stromal tumour; oestradiol
• B Sex cord-stromal tumour; inhibin B
• C Germ cell tumour; AFP
• D Sex cord-stromal tumour; oestradiol ✓

Explanation

Granulosa cell tumour is classified under Sex cord-stromal tumours by WHO classification. It secretes oestradiol predominantly, causing feminizing effects: in prepubertal girls it causes precocious puberty, and in adults it causes irregular menstrual bleeding, endometrial hyperplasia, or endometrial carcinoma. Inhibin B is an important serum tumour marker for granulosa cell tumour (used for monitoring recurrence), but the feminizing effects are due to oestradiol secretion. The Adult type has Call-Exner bodies on histology.

Reference: Shaw's Textbook of Gynaecology, 17th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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