Sex cord-stromal ovarian tumors can cause endocrine manifestations. Which tumor is MOST specifically associated with inhibin B as a serum tumor marker?

• A Granulosa cell tumor ✓
• B Sertoli-Leydig cell tumor
• C Fibrothecoma
• D Brenner tumor

Explanation

Granulosa cell tumors (both adult and juvenile types) are the primary producers of inhibin (particularly inhibin B) and anti-Müllerian hormone (AMH), which serve as sensitive tumor markers for diagnosis, monitoring, and detecting recurrence. Estrogen production causes endometrial hyperplasia and vaginal bleeding in post-menopausal women. Sertoli-Leydig cell tumors produce androgens (testosterone, DHEA). Fibrothecomas and Brenner tumors generally do not produce hormones.

Reference: Shaw's Textbook of Gynaecology, 17th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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