Granulosa cell tumors of the ovary (adult type) are characterized by Call-Exner bodies histologically and secrete which hormone leading to its associated endometrial pathology?
- A Progesterone leading to decidualization
- B Testosterone leading to virilization
- C Inhibin B leading to FSH suppression only
- D Estrogen leading to endometrial hyperplasia/carcinoma ✓
Explanation
Adult granulosa cell tumors (GCTs) secrete estrogen, which causes endometrial stimulation; 5–10% of patients develop concurrent endometrial carcinoma, and up to 50% have endometrial hyperplasia. This is why endometrial sampling is mandatory before surgery in women with GCTs. Call-Exner bodies (small follicle-like spaces filled with eosinophilic material surrounded by granulosa cells) are the pathognomonic histological feature. Inhibin A and B are the best tumor markers for GCT and are used for monitoring recurrence. Juvenile GCT occurs in young girls and may present with precocious puberty due to hyperestrogenism.
Reference: Shaw's Textbook of Gynaecology, 17th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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