Which ovarian tumour is characterised by the histological presence of Call-Exner bodies and produces oestrogen leading to endometrial hyperplasia?

• A Sertoli-Leydig cell tumour
• B Thecoma
• C Granulosa cell tumour ✓
• D Fibroma

Explanation

Granulosa cell tumour (GCT) is a sex cord-stromal tumour that secretes oestrogen and is characterised by Call-Exner bodies — small follicle-like structures with eosinophilic fluid surrounded by granulosa cells, resembling primordial follicles. Oestrogenic hyperstimulation leads to endometrial hyperplasia (5–10% risk of endometrial carcinoma). Thecoma also produces oestrogen but lacks Call-Exner bodies. Sertoli-Leydig tumours produce androgens causing virilisation. Fibroma is hormonally inert and associated with Meigs syndrome.

Reference: Shaw's Textbook of Gynaecology, 17th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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