BRCA1 mutation in ovarian cancer is associated with which histological subtype that demonstrates BRCA1/2-associated prognosis?

• A Mucinous adenocarcinoma
• B High-grade serous ovarian carcinoma (HGSOC) ✓
• C Endometrioid carcinoma
• D Clear cell carcinoma

Explanation

BRCA1 and BRCA2 germline mutations are predominantly associated with high-grade serous ovarian carcinoma (HGSOC), the most common and lethal subtype. BRCA-mutated HGSOC paradoxically has a better response to platinum-based chemotherapy and PARP inhibitors (olaparib, niraparib) due to impaired homologous recombination DNA repair. Mucinous carcinomas have low BRCA mutation rates; clear cell and endometrioid are associated with endometriosis rather than BRCA mutations.

Reference: Shaw's Textbook of Gynaecology, 17th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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