BRCA1 and BRCA2 mutations are associated with hereditary ovarian cancer. Which histological subtype of epithelial ovarian cancer is NOT typically associated with BRCA mutations?

• A High-grade serous ovarian carcinoma
• B Mucinous ovarian carcinoma ✓
• C Fallopian tube carcinoma
• D Primary peritoneal carcinoma

Explanation

BRCA1/2 mutations strongly predispose to high-grade serous carcinoma of the ovary, fallopian tube, and peritoneum — all now considered a single disease entity (high-grade serous carcinoma). Mucinous ovarian carcinoma is not associated with BRCA mutations and has a distinct molecular profile (KRAS mutations). Mucinous carcinomas are often primary peritoneal or metastatic from GI/appendiceal primary rather than true ovarian. BRCA-mutated tumors are PARP inhibitor-sensitive.

Reference: Shaw's Textbook of Gynaecology, 17th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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