A 24-year-old woman has a 10 cm right ovarian cyst with elevated serum AFP (450 ng/mL) and normal CA-125 and LDH. The MOST LIKELY diagnosis is:
- A Serous carcinoma
- B Yolk sac tumor (endodermal sinus tumor) ✓
- C Dysgerminoma
- D Immature teratoma
Correct answer: B. Yolk sac tumor (endodermal sinus tumor)
Explanation
Yolk sac tumor (endodermal sinus tumor) is the most AFP-secreting germ cell tumor; AFP levels are markedly elevated (often >1000 ng/mL in advanced cases). Dysgerminoma elevates LDH and beta-hCG, not AFP. Choriocarcinoma elevates beta-hCG. Immature teratoma may slightly elevate AFP but not to the degree seen in yolk sac tumor. This is the classic tumor marker–histology pairing tested in NEET PG.
Reference: Shaw's Textbook of Gynaecology, 17th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.