A 28-year-old woman at 30 weeks gestation presents with new-onset hypertension and borderline proteinuria. An sFlt-1/PlGF ratio is measured to predict the likelihood of developing pre-eclampsia requiring delivery. According to the PROGNOSIS study, which ratio value reliably rules out pre-eclampsia within the next week?
- A < 8
- B < 38 ✓
- C > 38
- D > 85
Correct answer: B. < 38
Explanation
An sFlt-1/PlGF ratio of less than 38 has a high negative predictive value and reliably rules out the development of pre-eclampsia requiring delivery within the next week. A ratio greater than 38 is associated with an increased risk of developing pre-eclampsia within the next four weeks.
Reference: Williams Obstetrics, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.