HELLP syndrome is a severe variant of pre-eclampsia. Which of the following laboratory combinations is DIAGNOSTIC of complete HELLP syndrome?

• A Hemolysis + elevated creatinine + low platelets
• B Elevated liver enzymes + thrombocytopenia + elevated uric acid
• C Microangiopathic hemolytic anemia + elevated BUN + proteinuria
• D Hemolysis + elevated liver enzymes + low platelets ✓

Explanation

HELLP syndrome stands for Hemolysis (H), Elevated Liver enzymes (EL), and Low Platelets (LP). The Tennessee Classification defines complete HELLP as LDH >600 U/L (hemolysis), AST/ALT >70 U/L (elevated liver enzymes), and platelets <100,000/µL. Platelet transfusion is indicated if platelets fall below 20,000/µL before delivery. Delivery is the definitive treatment regardless of gestational age when complete HELLP is diagnosed.

Reference: Williams Obstetrics, 26th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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