A 35-year-old woman with a history of pre-eclampsia in her previous pregnancy presents for preconception counseling. She asks about long-term health risks. Which of the following cardiovascular risks is most strongly associated with a history of early-onset pre-eclampsia?
- A Peripheral arterial disease
- B Deep vein thrombosis
- C Ischemic heart disease and stroke ✓
- D Aortic dissection
Correct answer: C. Ischemic heart disease and stroke
Explanation
A history of pre-eclampsia, particularly early-onset or severe disease, is associated with a 3-4 fold increased lifetime risk of ischemic heart disease and a 2-3 fold increased risk of stroke, as recognized by the American Heart Association. This reflects shared endothelial dysfunction and cardiovascular risk factors. Peripheral arterial disease, DVT, and aortic dissection are not as strongly linked to pre-eclampsia history.
Reference: Harrison's Principles of Internal Medicine, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.