Which antihypertensive class is absolutely contraindicated throughout pregnancy because of its fetotoxic profile?

• A Calcium channel blockers
• B Angiotensin-converting enzyme inhibitors ✓
• C Alpha-methyldopa
• D Beta blockers

Explanation

ACE inhibitors cause fetal renal failure leading to oligohydramnios, limb contractures, cranial calvarial hypoplasia, pulmonary hypoplasia, and neonatal death, particularly with exposure in the second and third trimesters, and they are avoided in pregnancy altogether. Calcium channel blockers, methyldopa, and labetalol are all established safe options used across gestation. The same fetotoxicity applies to angiotensin receptor antagonists, which is why they are substituted with safer agents before conception.

Reference: Katzung Basic and Clinical Pharmacology, 16th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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