Which antihypertensive drug class is absolutely contraindicated throughout pregnancy because of documented fetal renal injury?
- A Angiotensin receptor blockers ✓
- B Central alpha-2 agonists
- C Calcium channel blockers
- D Beta blockers
Correct answer: A. Angiotensin receptor blockers
Explanation
ACE inhibitors and angiotensin receptor blockers are contraindicated in all trimesters. They cross the placenta and impair fetal renal function, causing oligohydramnios, renal dysgenesis, calvarial hypoplasia, and fetal death, particularly with second and third trimester exposure. Labetalol, methyldopa, and calcium channel blockers such as nifedipine are established safe options used across pregnancy.
Reference: Katzung Basic and Clinical Pharmacology, 15th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.