Which of the following maternal conditions places a woman in the HIGH-RISK category for pre-eclampsia and mandates low-dose aspirin prophylaxis in a subsequent pregnancy?

• A Body mass index of 29 kg/m2
• B Nulliparity alone
• C Antiphospholipid antibody syndrome ✓
• D First-degree family history of pre-eclampsia

Explanation

Antiphospholipid antibody syndrome, previous pre-eclampsia, chronic hypertension, pregestational diabetes, chronic renal disease, and autoimmune disease such as systemic lupus erythematosus constitute the high-risk category warranting low-dose aspirin started in the first trimester. Nulliparity, obesity with BMI above 30, maternal age above 40, and family history are moderate-risk factors requiring more than one feature to justify aspirin. BMI of 29 falls below the moderate-risk threshold of 30, making options B through D insufficient alone.

Reference: Williams Obstetrics, 26th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.