The Magpie trial established which of the following regarding magnesium sulfate in pre-eclampsia?
- A It halves the risk of eclampsia in women with pre-eclampsia compared to placebo ✓
- B It reduces maternal mortality in eclampsia compared to diazepam
- C It improves perinatal survival when given before 28 weeks
- D It is superior to phenytoin in controlling established eclamptic seizures
Correct answer: A. It halves the risk of eclampsia in women with pre-eclampsia compared to placebo
Explanation
The Magpie Trial (2002) showed that magnesium sulfate given to women with pre-eclampsia reduces the risk of eclampsia by approximately 58% (about half) compared with placebo. It also showed a non-significant trend toward reduced maternal mortality. The Collaborative Eclampsia Trial demonstrated superiority over diazepam and phenytoin for treating established eclampsia, but that was a separate trial.
Reference: Williams Obstetrics, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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