First-trimester prediction of pre-eclampsia using the Fetal Medicine Foundation (FMF) combined screening model incorporates which combination of markers?
- A Age, BMI, and blood pressure measurement alone
- B Serum AFP, free β-hCG, and NT at 11–14 weeks
- C Mean arterial pressure, uterine artery pulsatility index, PAPP-A, and PlGF at 11–14 weeks ✓
- D Doppler of middle cerebral artery and umbilical artery velocimetry
Correct answer: C. Mean arterial pressure, uterine artery pulsatility index, PAPP-A, and PlGF at 11–14 weeks
Explanation
The FMF first-trimester combined pre-eclampsia screening at 11–14 weeks incorporates maternal history/characteristics, mean arterial pressure (MAP), uterine artery pulsatility index (UtA-PI) on Doppler, serum PAPP-A (pregnancy-associated plasma protein A), and PlGF (placental growth factor). This algorithm achieves approximately 77% detection rate for preterm PE at 10% FPR. PlGF is low in pregnancies destined to develop pre-eclampsia due to impaired placentation. AFP and free β-hCG are used in aneuploidy screening, not pre-eclampsia prediction.
Reference: Williams Obstetrics, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.