The PREVENT trial evaluated aspirin for pre-eclampsia prevention. According to this and related evidence, the recommended aspirin dose and timing of initiation for high-risk women is:

• A 75 mg daily from 12 to 16 weeks gestation
• B 100 mg daily from 20 weeks gestation
• C 325 mg alternate days from first trimester
• D 150 mg nightly from 11 to 14 weeks gestation ✓

Explanation

The ASPRE trial demonstrated that 150 mg aspirin taken at night starting at 11–14 weeks reduces pre-eclampsia risk by approximately 62% in high-risk women identified by first-trimester combined screening. Nighttime administration improves compliance and bioavailability. The PREVENT trial further validated aspirin prophylaxis; lower doses (75–100 mg) have some evidence but 150 mg nightly is the evidence-based recommendation for high-risk women.

Reference: Williams Obstetrics, 26th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.