The MAGPIE trial established which of the following regarding magnesium sulphate in pre-eclampsia?
- A It reduces maternal mortality by 50% compared to placebo
- B It halves the risk of eclampsia and is associated with reduced risk of placental abruption ✓
- C It reduces the risk of preterm birth in women with severe pre-eclampsia
- D It decreases perinatal mortality when compared to diazepam
Correct answer: B. It halves the risk of eclampsia and is associated with reduced risk of placental abruption
Explanation
The MAGPIE trial (2002) demonstrated that magnesium sulphate halves the risk of eclampsia and is associated with a reduced risk of placental abruption in women with pre-eclampsia. It did not significantly reduce maternal mortality and does not prevent preterm birth. The benefit applied across severe and non-severe pre-eclampsia.
Reference: Williams Obstetrics, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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