Regarding the first-trimester combined screening for pre-eclampsia (FMF algorithm), which combination of markers provides the BEST detection rate at 11–13 weeks?

• A Serum AFP + uterine artery Doppler + BMI
• B PAPP-A + β-hCG + nuchal translucency
• C Fetal biometry + uterine artery notching + serum inhibin A
• D Mean arterial pressure + uterine artery Pulsatility Index + PAPP-A + PlGF ✓

Explanation

The FMF first-trimester algorithm combining mean arterial pressure (MAP), uterine artery pulsatility index (UtA-PI), pregnancy-associated plasma protein A (PAPP-A), and placental growth factor (PlGF) detects ~75% of preterm pre-eclampsia and ~40% of term pre-eclampsia at a 10% false-positive rate at 11–13+6 weeks. This quadruple marker approach (plus maternal factors) forms the basis of the ASPRE trial screening. AFP and inhibin A are second-trimester markers; nuchal translucency is for aneuploidy, not pre-eclampsia screening.

Reference: Williams Obstetrics, 26th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.