In the MAGPIE trial, magnesium sulfate was shown to reduce the risk of which outcome compared with placebo in women with pre-eclampsia?
- A Maternal mortality
- B Eclampsia ✓
- C Perinatal mortality
- D Placental abruption
Correct answer: B. Eclampsia
Explanation
The MAGPIE trial (2002) demonstrated that magnesium sulfate halves the risk of eclampsia in women with pre-eclampsia compared with placebo. It did not show a statistically significant reduction in maternal mortality or perinatal mortality in that trial. This evidence established magnesium as the anticonvulsant of choice for eclampsia prophylaxis.
Reference: Williams Obstetrics, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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