The CHIPS (Control of Hypertension in Pregnancy Study) trial demonstrated that compared to 'less tight' control, 'tight' control of non-severe hypertension in pregnancy to a target diastolic of 85 mmHg:
- A Significantly reduced preterm birth before 34 weeks
- B Increased intrauterine growth restriction without benefit to the mother
- C Did not increase serious perinatal complications but reduced progression to severe hypertension ✓
- D Reduced the rate of gestational diabetes in the treated group
Correct answer: C. Did not increase serious perinatal complications but reduced progression to severe hypertension
Explanation
The CHIPS trial (NEJM 2015) showed that tight control (target diastolic 85 mmHg) versus less-tight control (target diastolic 100 mmHg) significantly reduced progression to severe hypertension without increasing serious perinatal complications including low birth weight or IUGR. This trial provided evidence that treating non-severe hypertension in pregnancy is beneficial for the mother without fetal harm.
Reference: Williams Obstetrics, 26th ed.
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Written and medically reviewed by the StethoPrep medical team.