HELLP syndrome is best classified using the Mississippi classification. Class 1 HELLP is defined by which platelet count threshold?

• A Platelet count <150,000/µL
• B Platelet count <100,000/µL
• C Platelet count <150,000/µL with LDH >600 IU/L
• D Platelet count <50,000/µL ✓

Explanation

The Mississippi classification of HELLP syndrome (Martin 1999) grades severity by nadir platelet count: Class 1 = platelets ≤50,000/µL (most severe); Class 2 = 50,001–100,000/µL; Class 3 = 100,001–150,000/µL (partial HELLP). All classes also require LDH >600 IU/L and AST/ALT >70 IU/L. This is distinct from the Tennessee classification (complete vs incomplete HELLP), which does not sub-classify by platelet count.

Reference: Williams Obstetrics, 26th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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