The CHIPS (Control of Hypertension in Pregnancy Study) trial compared tight versus less-tight blood pressure control in pregnant women with chronic or gestational hypertension. Its main finding was:
- A Tight control reduced perinatal mortality compared to less-tight control
- B Less-tight control (target diastolic 100 mmHg) led to significantly better neonatal outcomes
- C Tight control (target diastolic 85 mmHg) significantly reduced the risk of severe maternal hypertension ✓
- D There was no difference in maternal or fetal outcomes between tight and less-tight control
Correct answer: C. Tight control (target diastolic 85 mmHg) significantly reduced the risk of severe maternal hypertension
Explanation
The CHIPS trial (2015, NEJM) randomised women with non-severe, non-proteinuric hypertension in pregnancy to tight (diastolic 85 mmHg) versus less-tight (diastolic 100 mmHg) control. The primary finding was that tight control significantly reduced the risk of severe maternal hypertension (≥160/110 mmHg) without increasing the risk of pregnancy loss, high-level neonatal care, or overall perinatal outcomes. This supported active BP treatment even in non-severe hypertension.
Reference: Williams Obstetrics, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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