Which antihypertensive agent is CONTRAINDICATED in pregnancy due to risk of fetal renal tubular dysplasia and oligohydramnios when used after the first trimester?
- A Labetalol
- B Enalapril ✓
- C Nifedipine
- D Methyldopa
Correct answer: B. Enalapril
Explanation
ACE inhibitors (e.g., enalapril) and ARBs are contraindicated after the first trimester because they cause fetal renal tubular dysplasia, severe oligohydramnios, renal failure, limb contractures, and skull ossification defects. Labetalol, nifedipine, and methyldopa are all acceptable antihypertensives in pregnancy with established safety profiles.
Reference: Williams Obstetrics, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.