The CHIPS (Control of Hypertension in Pregnancy Study) trial compared 'tight' (target diastolic 85 mmHg) versus 'less-tight' (target diastolic 100 mmHg) control in non-severe hypertension in pregnancy. The primary finding was:
- A Tight control reduced serious maternal complications without increasing perinatal harm ✓
- B Tight control significantly reduced perinatal mortality
- C Tight control was associated with significant fetal growth restriction
- D Less-tight control reduced progression to severe hypertension
Correct answer: A. Tight control reduced serious maternal complications without increasing perinatal harm
Explanation
The CHIPS trial (NEJM 2015) demonstrated that tight control (target diastolic 85 mmHg) significantly reduced the risk of serious maternal hypertensive complications (e.g., severe hypertension) compared to less-tight control, without a significant difference in the composite perinatal outcome. This contradicted the longstanding fear that tighter control would harm the fetus through uteroplacental insufficiency.
Reference: Williams Obstetrics, 26th ed.
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Written and medically reviewed by the StethoPrep medical team.