The CHIPS trial (Control of Hypertension in Pregnancy Study) compared 'less tight' (target diastolic 100 mmHg) versus 'tight' (target diastolic 85 mmHg) control of non-severe chronic or gestational hypertension in pregnancy. Which was the PRIMARY finding of this trial?
- A Tight control significantly reduced perinatal mortality
- B Tight control did not increase the risk of SGA babies but reduced maternal serious adverse outcomes ✓
- C Tight control halved the incidence of superimposed pre-eclampsia
- D Tight control doubled the rate of fetal growth restriction compared to less-tight control
Correct answer: B. Tight control did not increase the risk of SGA babies but reduced maternal serious adverse outcomes
Explanation
The CHIPS trial found that tight blood pressure control (target diastolic 85 mmHg) significantly reduced serious maternal hypertensive complications without increasing the rate of small-for-gestational-age infants or perinatal loss. It did not significantly reduce superimposed pre-eclampsia, and growth restriction rates were similar between groups.
Reference: Williams Obstetrics, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.