The CHIPS (Control of Hypertension in Pregnancy Study) trial compared tight control (target diastolic 85 mmHg) versus less tight control (target diastolic 100 mmHg) of non-severe hypertension in pregnancy. What was its primary conclusion?
- A Tight control significantly reduced the incidence of pre-eclampsia superimposed on chronic hypertension
- B Tight control halved the risk of progression to severe hypertension without worsening perinatal outcomes ✓
- C Tight control reduced pregnancy loss and high-level neonatal care admissions
- D Less tight control was associated with fewer SGA neonates and better fetal growth
Correct answer: B. Tight control halved the risk of progression to severe hypertension without worsening perinatal outcomes
Explanation
The CHIPS trial showed tight BP control (target diastolic 85 mmHg) significantly reduced the risk of progression to severe hypertension (diastolic ≥110 mmHg) without any increase in adverse perinatal outcomes (fetal/neonatal death, preterm birth, SGA) compared with less tight control. It did not show reduction in superimposed pre-eclampsia or pregnancy loss. This trial supports treating non-severe hypertension in pregnancy to a moderate target.
Reference: Williams Obstetrics, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.