In the sFlt-1:PlGF ratio-guided management of suspected pre-eclampsia, a ratio of ≤38 at 24–36+6 weeks gestation indicates:
- A High likelihood of developing pre-eclampsia within 4 weeks
- B Immediate delivery is indicated to prevent maternal deterioration
- C Pre-eclampsia can be ruled out within the next 1 week with high negative predictive value ✓
- D The patient requires prophylactic low-dose aspirin from this point onwards
Correct answer: C. Pre-eclampsia can be ruled out within the next 1 week with high negative predictive value
Explanation
An sFlt-1:PlGF ratio of ≤38 has a very high negative predictive value (~99%) for ruling out pre-eclampsia within 1 week. This allows safe discharge and avoidance of unnecessary hospitalization. A ratio >38 is associated with development of pre-eclampsia, and a ratio >85 (or >110 before 34 weeks) is associated with imminent need for delivery. The ratio is used alongside clinical parameters to guide triage decisions.
Reference: Williams Obstetrics, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.