sFlt-1/PlGF ratio is used as a biomarker in suspected preeclampsia. According to current NICE 2023 guidance, a ratio below which threshold helps RULE OUT preeclampsia developing within the next 1 week in women presenting at 20–34+6 weeks with suspected preeclampsia?
- A 85
- B 38 ✓
- C 110
- D 200
Correct answer: B. 38
Explanation
NICE 2023 guidance on the Elecsys sFlt-1/PlGF test recommends using a cutoff of <38 to effectively rule out preeclampsia development within the next 7 days (high negative predictive value ~99.3%), applicable at 20+0 to 34+6 weeks. A ratio ≥38 should prompt further evaluation and monitoring. Values >85 are associated with imminent or severe preeclampsia and may trigger intervention. This ratio outperforms proteinuria and BP alone as a triage tool and is particularly useful in the day assessment unit setting.
Reference: Williams Obstetrics, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.