The MAGPIE trial (2002) established magnesium sulfate as the drug of choice for eclampsia prophylaxis in women with pre-eclampsia. Which of the following outcomes was NOT demonstrated in MAGPIE?
- A 50% reduction in risk of eclampsia compared to placebo
- B Significant reduction in maternal mortality ✓
- C Reduction in placental abruption risk
- D No significant difference in perinatal death rates
Correct answer: B. Significant reduction in maternal mortality
Explanation
The MAGPIE trial showed a 58% relative risk reduction in eclampsia with magnesium sulfate versus placebo and also showed a reduction in placental abruption. However, it did not demonstrate a statistically significant reduction in maternal mortality (though there was a trend), and perinatal mortality was not significantly different. Option B is thus what was NOT demonstrated — maternal mortality reduction was not statistically proven in MAGPIE.
Reference: Williams Obstetrics, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.