The angiogenic biomarker ratio most validated for predicting short-term risk of pre-eclampsia and guiding triage in suspected cases is:
- A sFlt-1 : PlGF ratio ✓
- B PlGF : VEGF ratio
- C Endoglin : PlGF ratio
- D PP13 : PAPP-A ratio
Correct answer: A. sFlt-1 : PlGF ratio
Explanation
The sFlt-1:PlGF (soluble fms-like tyrosine kinase-1 to placental growth factor) ratio has been validated in large prospective studies (including the PROGNOSIS trial) for ruling out pre-eclampsia within 1 week (ratio ≤38) and predicting development within 4 weeks. A ratio >85 correlates with high risk of imminent severe disease. It is incorporated into FIGO and NICE guidelines for triage. PlGF:VEGF is not the validated ratio; endoglin and PP13 are research markers.
Reference: Williams Obstetrics, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.