In the CHIPS (Control of Hypertension in Pregnancy Study) trial, 'tight' blood pressure control (target diastolic 85 mmHg) compared to 'less tight' control (target 100 mmHg) in non-severe gestational hypertension was associated with which primary finding?
- A Significant reduction in fetal growth restriction
- B Reduced incidence of severe maternal hypertension without increasing small-for-gestational-age births ✓
- C Improved neonatal neurodevelopmental outcomes at 2 years
- D Lower rate of preterm birth before 34 weeks
Correct answer: B. Reduced incidence of severe maternal hypertension without increasing small-for-gestational-age births
Explanation
The CHIPS trial demonstrated that tight diastolic control (target 85 mmHg) halved the risk of developing severe hypertension (>160/110 mmHg) compared to less-tight control (target 100 mmHg) without a significant increase in small-for-gestational-age neonates or adverse perinatal outcomes. This established the safety and efficacy of treating non-severe hypertension in pregnancy. Options A, C, and D were not the primary endpoints demonstrated.
Reference: Williams Obstetrics, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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