The ASPRE trial demonstrated that first-trimester combined screening (uterine artery Doppler, PAPP-A, MAP) followed by low-dose aspirin (150 mg nightly) from 11–14 weeks can reduce preterm pre-eclampsia (<37 weeks) by approximately what percentage?
- A 62% ✓
- B 15–20%
- C 35–40%
- D 82%
Correct answer: A. 62%
Explanation
The ASPRE trial (2017) showed that high-risk women identified by the Fetal Medicine Foundation first-trimester combined algorithm who took aspirin 150 mg nightly from 11–14 weeks had a 62% reduction in preterm pre-eclampsia (<37 weeks). The algorithm uses maternal factors, mean arterial pressure, uterine artery pulsatility index, and serum PAPP-A/PlGF to identify the top ~10% risk group. This screening-and-prevention approach represents a paradigm shift from reactive to proactive management. The Number Needed to Treat to prevent one case of preterm pre-eclampsia was approximately 37.
Reference: Williams Obstetrics, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.