The CHIPS (Control of Hypertension In Pregnancy Study) trial compared tight versus less-tight blood pressure control in non-severe hypertension in pregnancy. Which outcome was significantly different between the two groups?

• A Incidence of severe maternal hypertension was lower in tight control group ✓
• B Perinatal mortality was significantly reduced in tight control group
• C Rate of placental abruption was significantly lower in less-tight control group
• D Development of proteinuria progressing to pre-eclampsia was reduced in tight control group

Explanation

The CHIPS trial (2015, NEJM) showed that tight control (target diastolic 85 mmHg) significantly reduced serious maternal hypertension compared to less-tight control (target diastolic 100 mmHg). However, there was no significant difference in perinatal death, high-level neonatal care, or overall pregnancy loss between groups. The trial guided current recommendations for treating non-severe hypertension to a target of 130-140/80-85 mmHg. Abruption rates did not differ significantly.

Reference: Williams Obstetrics, 26th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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