In the CHIPS (Control of Hypertension In Pregnancy Study) trial, tight control of non-severe hypertension in pregnancy (target diastolic 85 mmHg) compared to less-tight control (target diastolic 100 mmHg) resulted in which of the following?

• A Significantly reduced rate of pre-eclampsia superimposition
• B Higher rate of small-for-gestational-age neonates
• C Increased rate of preterm delivery before 34 weeks
• D No difference in perinatal loss but fewer severe maternal hypertension episodes ✓

Explanation

The CHIPS trial demonstrated that tight blood pressure control (target diastolic 85 mmHg) did not reduce perinatal outcomes differently from less-tight control but significantly reduced the occurrence of severe maternal hypertension episodes without increasing SGA neonates. This trial supports individualized BP targets in pregnancy. Options A and D were not primary findings, and SGA rates were similar between groups.

Reference: Williams Obstetrics, 26th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.