The ASPRE trial established that low-dose aspirin started before 16 weeks reduces preterm pre-eclampsia risk by approximately what percentage in high-risk women identified by first-trimester combined screening?
- A 15–20%
- B 62% ✓
- C 30–35%
- D 82%
Correct answer: B. 62%
Explanation
The ASPRE (Aspirin for Evidence-Based Pre-eclampsia Prevention) trial demonstrated that low-dose aspirin (150 mg/day) started at 11–14 weeks in high-risk women identified by first-trimester combined screening (uterine artery Doppler, MAP, PlGF, PAPP-A) reduced preterm pre-eclampsia by approximately 62% (RR 0.38). The number needed to treat was about 7 for high-risk women. This established first-trimester risk stratification and aspirin prophylaxis as standard of care.
Reference: Williams Obstetrics, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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