Which of the following antihypertensives is absolutely contraindicated in pregnancy because of fetal renal tubular dysplasia and oligohydramnios?

• A Labetalol
• B Nifedipine
• C Methyldopa
• D Enalapril ✓

Explanation

ACE inhibitors (e.g., enalapril) are absolutely contraindicated in pregnancy; their use in the second and third trimesters causes fetal hypotension, oliguria, renal tubular dysplasia, oligohydramnios, and skull ossification defects — collectively the 'ACE inhibitor fetopathy'. Labetalol, nifedipine, and methyldopa are all safe and commonly used antihypertensives in pregnancy.

Reference: Williams Obstetrics, 26th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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