A 58-year-old man presents with multiple firm yellowish papules on the face, histologically confirmed as sebaceous adenomas. Which additional clinical step is indicated?
- A Serological testing for HIV
- B Screening for Lynch syndrome-associated internal malignancies ✓
- C Measurement of serum androgen levels
- D Colonoscopy for familial adenomatous polyposis specifically
Correct answer: B. Screening for Lynch syndrome-associated internal malignancies
Explanation
Multiple sebaceous adenomas, especially with sebaceous carcinoma or keratoacanthomas, define Muir-Torre syndrome, a phenotypic variant of Lynch syndrome caused by mismatch repair gene mutations. Affected patients need screening for colorectal, endometrial and other Lynch-associated cancers. HIV testing relates to eruptive sebaceous hyperplasia-like lesions in some reports but is not the classic association. Serum androgens relate to acne and hirsutism, and FAP is a distinct polyposis syndrome not defined by sebaceous tumours.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.