Isotretinoin (13-cis retinoic acid) is the only drug that addresses all four pathogenic factors in acne vulgaris. Its PRIMARY mechanism of action in acne is:
- A Sebaceous gland atrophy and reduction of sebum production ✓
- B Inhibition of Cutibacterium acnes directly
- C Blockade of androgen receptors in pilosebaceous units
- D Inhibition of lipoxygenase-mediated inflammation
Correct answer: A. Sebaceous gland atrophy and reduction of sebum production
Explanation
Isotretinoin's primary and most distinctive action is induction of sebaceous gland atrophy, reducing sebum output by >90%. This addresses the root cause (excess sebum) and secondarily reduces the anaerobic environment sustaining C. acnes colonisation, decreases follicular hyperkeratinisation, and suppresses inflammation. No other acne drug achieves this degree of sebum suppression. It is indicated for severe nodulo-cystic acne, resistant moderate acne, and acne causing significant scarring or psychosocial distress.
Reference: Neena Khanna Illustrated Synopsis of Dermatology & STD, 6th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.