Fox-Fordyce disease is a disorder of which adnexal structure, and what is its characteristic histological finding?
- A Eccrine sweat glands; dilated eccrine ducts with periductal fibrosis
- B Apocrine sweat glands; follicular infundibular keratin plugging with apocrine duct obstruction ✓
- C Sebaceous glands; sebaceous hyperplasia with ectopic sebocytes
- D Hair follicle; perifollicular granuloma with fibrosis
Correct answer: B. Apocrine sweat glands; follicular infundibular keratin plugging with apocrine duct obstruction
Explanation
Fox-Fordyce disease is a chronic pruritic disorder of apocrine sweat glands, presenting as flesh-coloured or pigmented papules in axillae, pubic area, and areolae, predominantly in women post-puberty. Histology shows: follicular infundibular keratinous plugging obstructing the apocrine duct ostium, leading to duct dilatation and rupture. Treatment includes topical retinoids, clindamycin, and oral contraceptives.
Reference: Neena Khanna Illustrated Synopsis of Dermatology & STD, 6th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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