Under the National Tuberculosis Elimination Programme (NTEP), the TB Preventive Therapy (TPT) regimen recommended for household contacts aged ≥5 years with a positive TST/IGRA and no active TB is:

• A Isoniazid 5 mg/kg/day for 6 months (6H) ✓
• B Isoniazid + Rifapentine weekly for 12 weeks (3HP)
• C Rifampicin daily for 4 months (4R) as the preferred regimen for all adults
• D Isoniazid alone for 9 months (9H) exclusively

Explanation

Under NTEP India's updated guidelines aligned with the National Strategic Plan 2017–2025, household contacts ≥5 years who are TST/IGRA-positive without active TB receive Isoniazid 5 mg/kg/day (max 300 mg/day) for 6 months (6H) as TPT. The 3HP regimen (Isoniazid + Rifapentine weekly for 12 weeks) is recommended by WHO and has been piloted in India but is not yet the standard national protocol. TPT for children <5 years uses 6H regardless of TST status.

Reference: Park's Textbook of Preventive and Social Medicine, 27th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.