Community Medicine (PSM) · Epidemiology (Study Designs, Bias, Systematic Review, Measures of Association)

Which of the following is the BEST measure of the strength of association between smoking and lung cancer in a case-control study?

  • A Relative Risk (RR)
  • B Attributable Risk (AR)
  • C Population Attributable Risk (PAR)
  • D Odds Ratio (OR)
Correct answer: D. Odds Ratio (OR)

Explanation

In case-control studies, incidence cannot be directly calculated (as you start with cases and controls, not a defined population at risk), so Relative Risk cannot be computed directly. The Odds Ratio (OR) is the appropriate measure of association in case-control studies and approximates RR when disease prevalence is low (<10%). Attributable Risk and PAR require incidence data from cohort or experimental studies.

Reference: Park's Textbook of Preventive and Social Medicine, 27th ed.

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