A researcher wants to control for multiple confounders simultaneously in a case-control study examining oral contraceptive use and breast cancer. The most appropriate analytical technique is:
- A Logistic regression ✓
- B Mantel-Haenszel stratification
- C Paired t-test
- D Chi-square with Yates correction
Correct answer: A. Logistic regression
Explanation
Logistic regression allows simultaneous control of multiple confounders in a case-control study with a binary outcome. Mantel-Haenszel stratification is useful but becomes inefficient with many confounders due to sparse data in strata. Paired t-test and chi-square with Yates correction do not adjust for multiple confounders simultaneously.
Reference: Park's Textbook of Preventive and Social Medicine, 27th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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