In a study evaluating the effect of a 4-week yoga intervention on fasting blood glucose, measurements are taken on 25 participants before and after the intervention. The appropriate statistical test to compare the mean difference is:

• A Independent samples t-test
• B One-way ANOVA
• C Chi-square test
• D Paired t-test ✓

Explanation

A paired t-test is used when measurements are taken from the same subjects under two different conditions (before and after). The analysis focuses on the within-subject differences. An independent t-test would be used for two separate groups. ANOVA is for comparing more than two groups. Chi-square is for categorical data, not continuous glucose measurements.

Reference: B K Mahajan's Methods in Biostatistics, 7th ed.

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