A study compares pre-treatment and post-treatment blood pressure in the same 25 patients using a new antihypertensive. The appropriate statistical test is:
- A Paired t-test ✓
- B Independent samples t-test
- C Chi-square test
- D ANOVA
Correct answer: A. Paired t-test
Explanation
The same subjects are measured before and after treatment, making the observations paired or dependent. The paired t-test accounts for within-subject correlation. The independent t-test assumes two separate groups. Chi-square tests proportions, not continuous means. ANOVA compares more than two independent groups. This distinction between paired and independent tests is repeatedly examined.
Reference: Methods in Biostatistics, 7th ed.
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