A biostatistician wants to compare blood pressure measurements before and after a yoga intervention in the same group of hypertensive patients. The most appropriate statistical test is:

• A Unpaired t-test
• B Chi-square test
• C One-way ANOVA
• D Paired t-test ✓

Explanation

A paired t-test is appropriate when comparing two related measurements from the same subjects (before and after data). The paired design controls for inter-individual variability, making it more powerful than the unpaired t-test. The unpaired t-test compares two independent groups; chi-square is for categorical data; ANOVA compares means of three or more groups.

Reference: Park's Textbook of Preventive and Social Medicine, 27th ed.

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