In a meta-analysis, the I² statistic is reported as 72%. This indicates:
- A No significant heterogeneity between studies
- B Moderate heterogeneity
- C Substantial heterogeneity that may limit pooling ✓
- D That 72% of studies showed a significant effect
Correct answer: C. Substantial heterogeneity that may limit pooling
Explanation
I² measures the percentage of total variation across studies due to heterogeneity rather than chance. I² of 0–25% = low, 25–50% = moderate, 50–75% = substantial, >75% = considerable heterogeneity. An I² of 72% represents substantial heterogeneity, which should prompt subgroup analysis and caution when interpreting the pooled estimate. It does not refer to the proportion of studies with significant results.
Reference: Park's Textbook of Preventive and Social Medicine, 27th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.