A meta-analysis combines results from 8 randomised trials on antihypertensive therapy. The I² statistic is 75%. This indicates:
- A 75% of trials show statistically significant results
- B 75% of the variability in effect estimates is due to heterogeneity rather than chance ✓
- C The pooled odds ratio has a 75% confidence interval
- D The meta-analysis has 75% statistical power
Correct answer: B. 75% of the variability in effect estimates is due to heterogeneity rather than chance
Explanation
I² quantifies the proportion of total variation across studies attributable to heterogeneity rather than sampling error. Values: <25% low, 25–50% moderate, 50–75% high, >75% very high heterogeneity. An I² of 75% means substantial unexplained between-study variation, calling for a random-effects model and caution in pooling.
Reference: Park's Textbook of Preventive and Social Medicine, 27th ed.
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