In a randomized controlled trial, 200 patients received a new drug and 200 received placebo. Events occurred in 40 drug group and 60 placebo group patients. What is the Number Needed to Treat (NNT)?

• A 5
• B 20
• C 3
• D 10 ✓

Explanation

Absolute Risk Reduction (ARR) = Risk in control – Risk in intervention = (60/200) – (40/200) = 0.30 – 0.20 = 0.10. NNT = 1/ARR = 1/0.10 = 10. NNT represents the number of patients who need to be treated to prevent one additional adverse event.

Reference: Park's Textbook of Preventive and Social Medicine, 27th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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