The IAP Advisory Committee on Vaccines and Immunization Practices (ACVIP) 2023 revised schedule includes two categories of vaccines. In a child with moderate-to-severe acute febrile illness, which vaccines are CONTRAINDICATED until recovery?

• A All vaccines are safe to give during any illness
• B All vaccines should be deferred until full recovery from any febrile illness ✓
• C Only live-attenuated vaccines (OPV, MMR, varicella) should be deferred
• D Only inactivated vaccines are affected by fever

Explanation

Moderate-to-severe acute febrile illness is a valid temporary contraindication for ALL vaccines, not just live-attenuated ones, to avoid attributing adverse events of the illness to the vaccine and to ensure optimal immune response. Mild illness (mild cough, cold, low-grade fever) is NOT a contraindication — these are false contraindications and should not delay vaccination. Live vaccines (OPV, MMR, varicella) have additional specific contraindications (immunosuppression). Once the child recovers, all missed vaccines should be given using a catch-up schedule.

Reference: Ghai Essential Pediatrics, 10th ed.

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Written and medically reviewed by the StethoPrep medical team.