In the Indian National Immunization Schedule, the fractional dose IPV strategy is used. Which of the following CORRECTLY describes the fractional dose IPV administration in India?

• A 1/2 of the standard dose (0.25 mL) given subcutaneously at 6 and 10 weeks
• B Full intramuscular dose (0.5 mL) given as a booster at 14 weeks to replace OPV
• C 1/5th of the standard intramuscular dose (0.1 mL) given intradermally at 6 and 14 weeks ✓
• D 1/5th dose (0.1 mL) given intradermally at 6, 14 weeks and 9 months as 3 doses

Explanation

India's National Immunization Programme uses fractional dose IPV (fIPV) to expand coverage: 1/5th of the standard 0.5 mL IM dose (i.e., 0.1 mL) is given intradermally at 6 weeks and 14 weeks. Intradermal administration of this fractional dose elicits an immune response comparable to the full IM dose due to the high density of dendritic cells in the skin. This strategy conserves vaccine supply. The schedule is 2 fIPV doses (at 6 and 14 weeks), not 3 doses and not at 9 months.

Reference: Ghai Essential Pediatrics, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.